Tailored therapeutics based on 1,2,3-1-triazoles: a mini review.

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ID: 50520
2019
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Abstract
Contemporary drug discovery approaches rely on library synthesis coupled with combinatorial methods and high-throughput screening to identify leads. However, due to the multitude of components involved, a majority of optimization techniques face persistent challenges related to the efficiency of synthetic processes and the purity of compound libraries. These methods have recently found an upgradation as fragment-based approaches for target-guided synthesis of lead molecules with active involvement of their biological target. The click chemistry approach serves as a promising tool for tailoring the therapeutically relevant biomolecules of interest, improving their bioavailability and bioactivity and redirecting them as efficacious drugs. 1,2,3-1-Triazole nucleus, being a planar and biologically acceptable scaffold, plays a crucial role in the design of biomolecular mimetics and tailor-made molecules with therapeutic relevance. This versatile scaffold also forms an integral part of the current fragment-based approaches for drug design, kinetic target guided synthesis and bioorthogonal methodologies.
Reference Key
prasher2019tailoredmedchemcomm Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Prasher, Parteek;Sharma, Mousmee;
Journal medchemcomm
Year 2019
DOI
10.1039/c9md00218a
URL
Keywords
1,2,4-triazole molecular docking antiproliferation combretastatin a-4 tubulin

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