New Poly(Propylene Imine) Dendrimer Modified with Acridine and Its Cu(II) Complex: Synthesis, Characterization and Antimicrobial Activity.

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ID: 50265
2019
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Ranked #238 of 812 articles by views in Materials (Basel, Switzerland)

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Abstract
A second-generation poly(propylene imine) dendrimer modified with acridine and its Cu(II) complex have been synthesized for the first time. It has been found that two copper ions form complexes with the nitrogen atoms of the dendrimeric core by coordinate bonds. The new compounds have been characterized by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), fourier-transform infrared spectroscopy (FTIR) and fluorescence spectroscopy. The spectral characteristics of the modified dendrimer have been measured in different organic solvents, and a negative fluorescence solvatochromism has been observed. The antimicrobial activity of the dendrimers has been tested against model pathogenic microorganisms in agar and by broth dilution method. The cotton fabric treated with both dendrimers has been evaluated towards pathogenic microorganisms. The obtained modified cotton fabrics have been shown to hamper bacterial growth and to prevent biofilm formation. Dendrimer cytotoxicity has been investigated in vitro in the model HEp-2 cell line.
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bosch2019newmaterials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bosch, Paula;Staneva, Desislava;Vasileva-Tonkova, Evgenia;Grozdanov, Petar;Nikolova, Ivanka;Kukeva, Rositsa;Stoyanova, Radostina;Grabchev, Ivo;
Journal Materials (Basel, Switzerland)
Year 2019
DOI
E3020
URL
Keywords
Antimicrobial activity acridine antibacterial cotton dendrimer metallodendrimer stress pregnancy infertility cortisol white-rot fungi atr-ftir corn digestate lignin degradation mushroom cultivation

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