Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics.

Clicks: 479
ID: 50255
2019
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Abstract
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.
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saarbach2019peptidecurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Saarbach, Jacques;Sabale, Pramod M;Winssinger, Nicolas;
Journal current opinion in chemical biology
Year 2019
DOI
S1367-5931(19)30008-0
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Keywords
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