Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Clicks: 292
ID: 4991
2009
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #29 of 75 articles by views in nature genetics

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide association studies (GWAS) of 3,393 cases and 12,462 controls. We used Gene Relationships Across Implicated Loci (GRAIL), a computational method that applies statistical text mining to PubMed abstracts, to score these 179 loci for functional relationships to genes in 16 established RA disease loci. We identified 22 loci with a significant degree of functional connectivity. We genotyped 22 representative SNPs in an independent set of 7,957 cases and 11,958 matched controls. Three were convincingly validated: CD2-CD58 (rs11586238, P = 1 x 10(-6) replication, P = 1 x 10(-9) overall), CD28 (rs1980422, P = 5 x 10(-6) replication, P = 1 x 10(-9) overall) and PRDM1 (rs548234, P = 1 x 10(-5) replication, P = 2 x 10(-8) overall). An additional four were replicated (P < 0.0023): TAGAP (rs394581, P = 0.0002 replication, P = 4 x 10(-7) overall), PTPRC (rs10919563, P = 0.0003 replication, P = 7 x 10(-7) overall), TRAF6-RAG1 (rs540386, P = 0.0008 replication, P = 4 x 10(-6) overall) and FCGR2A (rs12746613, P = 0.0022 replication, P = 2 x 10(-5) overall). Many of these loci are also associated to other immunologic diseases.
Reference Key
raychaudhuri2009geneticnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Raychaudhuri, Soumya;Thomson, Brian P;Remmers, Elaine F;Eyre, Stephen;Hinks, Anne;Guiducci, Candace;Catanese, Joseph J;Xie, Gang;Stahl, Eli A;Chen, Robert;Alfredsson, Lars;Amos, Christopher I;Ardlie, Kristin G;, ;Barton, Anne;Bowes, John;Burtt, Noel P;Chang, Monica;Coblyn, Jonathan;Costenbader, Karen H;Criswell, Lindsey A;Crusius, J Bart A;Cui, Jing;De Jager, Phillip L;Ding, Bo;Emery, Paul;Flynn, Edward;Harrison, Pille;Hocking, Lynne J;Huizinga, Tom W J;Kastner, Daniel L;Ke, Xiayi;Kurreeman, Fina A S;Lee, Annette T;Liu, Xiangdong;Li, Yonghong;Martin, Paul;Morgan, Ann W;Padyukov, Leonid;Reid, David M;Seielstad, Mark;Seldin, Michael F;Shadick, Nancy A;Steer, Sophia;Tak, Paul P;Thomson, Wendy;van der Helm-van Mil, Annette H M;van der Horst-Bruinsma, Irene E;Weinblatt, Michael E;Wilson, Anthony G;Wolbink, Gert Jan;Wordsworth, Paul;, ;Altshuler, David;Karlson, Elizabeth W;Toes, Rene E M;de Vries, Niek;Begovich, Ann B;Siminovitch, Katherine A;Worthington, Jane;Klareskog, Lars;Gregersen, Peter K;Daly, Mark J;Plenge, Robert M;
Journal nature genetics
Year 2009
DOI
10.1038/ng.479
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.