Pyromellitic Dianhydride Crosslinked Cyclodextrin Nanosponges for Curcumin Controlled Release; Formulation, Physicochemical Characterization and Cytotoxicity Investigations.

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ID: 49442
2019
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Abstract
In this study, a nanosponge structure was synthesized with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that has widely been considered due to its ability to treat cancer. FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Hemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% hemolysis in the lowest complex concentration (50μgml) and 5.09% at the highest concentration (200μgml). : Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system.
Reference Key
rafati2019pyromelliticjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rafati, Nesa;Zarrabi, Ali;Caldera, Fabrizio;Trotta, Francesco;Ghias, Narges;
Journal Journal of microencapsulation
Year 2019
DOI
10.1080/02652048.2019.1669728
URL
Keywords
curcumin anti-cancer solubility inclusion complex nanosponge

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