Encapsulation of glucose oxidase in Fe(III)/tannic acid nanocomposites for effective tumor ablation via Fenton reaction.

Clicks: 568
ID: 49441
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #1 of 107 articles by views in Nanotechnology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Increasing the content of reactive oxygen species (ROS) with the assistance of nanoformulations in cancer cells via Fenton reaction is considered to be an effective method to treat cancer. However, the efficiency of Fenton reaction is affected by the level of HO, the selection of iron ions in different nanoformulations, etc. Herein, we use the Fe-tannic acid (FeTA) nanocomposites as the carrier to deliver glucose oxidase (GOD) that can solve the problem of insufficient endogenous HO by catalytically converting the glucose. In comparison with traditional Fe/Fe, FeTA nanocomposites perform higher catalytic activity in converting HO to high toxic hydroxyl radicals (•OH) due to the TA-mediated reduction of Fe. So, the integration of GOD and TA in the construction of nanocomposites significantly enhances the efficiency of Fenton reaction. In vitro experiments show that •OH produced by GOD-Fe TA nanocomposites can not only achieve a good anticancer effect at a low concentration but also promote degradability of the nanocomposites. When it is only 1.08 μg•mL, the cell apoptosis rate has reached 76.91%. And in vivo experiments further demonstrate that GOD-FeTA nanocomposites can significantly inhibit the tumor growth. So this work lays a good foundation for Fenton reaction-based cancer treatment.
Reference Key
du2019encapsulationnanotechnology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Du, Keke;Liu, Qianqian;Liu, Mei;Lv, Rongmu;He, Nongyue;Wang, Zhifei;
Journal Nanotechnology
Year 2019
DOI
10.1088/1361-6528/ab44f9
URL
Keywords
catalysis fenton reaction glucose oxidase hydroxyl radicals iron ion

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.