Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug

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2012
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Abstract
The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions. SF-based films, spray-dried microparticles, and matrixes loaded with naproxen were prepared. Both FTIR spectra and in vitro dissolution data demonstrated that SF β-sheet conformation regulates the release profile of naproxen. The controlled release characteristics of the SF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents. The results suggest that SF may be an attractive polymer for use in controlled drug delivery systems.
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dyakonov2012designjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dyakonov, Tatyana;Yang, Chue Hue;Bush, Derek;Gosangari, Saujanya;Majuru, Shingai;Fatmi, Aqeel;
Journal journal of drug delivery
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2012/490514
Keywords
chemistry Pharmacy and materia medica Biology (General) Engineering (General). Civil engineering (General) Technology physics environmental sciences neurology. diseases of the nervous system medical physics. medical radiology. nuclear medicine neoplasms. tumors. oncology. including cancer and carcinogens water supply for domestic and industrial purposes sewage collection and disposal systems. sewerage Pharmacy and materia medica

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