Improved Dynamic Light Scattering using an adaptive and statistically driven time resolved treatment of correlation data.

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ID: 49291
2019
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Abstract
Dynamic Light Scattering (DLS) is a ubiquitous and non-invasive measurement for the characterization of nano- and micro-scale particles in dispersion. The sixth power relationship between scattered intensity and particle radius is simultaneously a primary advantage whilst rendering the technique sensitive to unwanted size fractions from unclean lab-ware, dust and aggregated & dynamically aggregating sample, for example. This can make sample preparation iterative, challenging and time consuming and often requires the use of data filtering methods that leave an inaccurate estimate of the steady state size fraction and may provide no knowledge to the user of the presence of the transient fractions. A revolutionary new approach to DLS measurement and data analysis is presented whereby the statistical variance of a series of individually analysed, extremely short sub-measurements is used to classify data as steady-state or transient. Crucially, all sub-measurements are reported, and no data are rejected, providing a precise and accurate measurement of both the steady state and transient size fractions. We demonstrate that this approach deals intrinsically and seamlessly with the transition from a stable dispersion to the partially- and fully-aggregated cases and results in an attendant improvement in DLS precision due to the shorter sub measurement length and the classification process used.
Reference Key
malm2019improvedscientific Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Malm, Alexander V;Corbett, Jason C W;
Journal Scientific reports
Year 2019
DOI
10.1038/s41598-019-50077-4
URL
Keywords
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