The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation.

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ID: 49281
2019
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Ranked #12 of 133 articles by views in materials science & engineering c, materials for biological applications

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Abstract
We report the first experimental evidence for the mitogenic action of cerium(IV) oxide and cerium(III) fluoride nanoparticles (CONs and CFNs) on the regeneration of a whole organism - freshwater flatworms Schmidtea mediterranea (planarian). Both types of cerium-containing nanoparticles are shown to be a highly potent mitogen for planaria. Both CONs and CFNs, in micro- and nanomolar concentrations, markedly accelerate planarian blastema growth, due to the enhancement of cellular proliferation, causing an increase in the mitotic index and in the quantity of blastema cells in regenerating planaria. CONs provided maximum activity at concentrations which were two orders of magnitude lower than those for CeF. The valence state of cerium in cerium-containing nanoparticles plays a significant role in the planarian regeneration mechanism: CeO nanoparticles containing predominantly Ce species presumably scavenge wound induced reactive oxygen species and moderately activate gene expression processes, while the regenerative action of CeF nanoparticles containing only Ce species is manifested in the pronounced expression of the genes involved in cell division, differentiation and migration. This is the first report on the effect of cerium-containing nanoparticles on tissue regeneration in vivo, further revealing the mechanisms of their biological action, which enhances the possibility of their use in cellular technologies.
Reference Key
ermakov2019thematerials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ermakov, Artem;Popov, Anton;Ermakova, Olga;Ivanova, Olga;Baranchikov, Alexander;Kamenskikh, Kristina;Shekunova, Taisiya;Shcherbakov, Alexander;Popova, Nelli;Ivanov, Vladimir;
Journal materials science & engineering c, materials for biological applications
Year 2019
DOI
S0928-4931(19)30472-2
URL
Keywords
nanoparticles regeneration cef(3) ceo(2) planaria

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