The Pattern of Signatures in Gastric Cancer Prognosis.

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ID: 49226
2018
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Abstract
Gastric cancer is one of the most common malignancies worldwide and it is a fourth leading cause of cancer-related death. Carcinogenesis is a multistage disease process specified by the gradual procurement of mutations and epigenetic alterations in the expression of different genes, which finally lead to the occurrence of a malignancy. These genes have diversified roles regarding cancer development. Intracellular pathways are assigned to the expression of different genes, signal transduction, cell-cycle supervision, genomic stability, DNA repair, and cell-fate destination, like apoptosis, senescence. Extracellular pathways embrace tumour invasion, metastasis, angiogenesis. Altered expression patterns, leading the different clinical responses. This review highlights the list of molecular biomarkers that can be used for prognostic purposes and provide information on the likely outcome of the cancer disease in an untreated individual.
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machlowska2018theinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Machlowska, Julita;Maciejewski, Ryszard;Sitarz, Robert;
Journal International journal of molecular sciences
Year 2018
DOI
E1658
URL
Keywords
apoptosis gastric cancer microsatellite instability her2 cell cycle regulators invasiveness mucins multidrug resistance proteins neovascularization peritoneal spreading

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