Recent advances in managing HIV-associated cryptococcal meningitis [version 1; peer review: 2 approved]

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2019
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Abstract
The recent development of highly sensitive and specific point-of-care tests has made it possible to diagnose HIV-associated cryptococcal meningitis within minutes. However, diagnostic advances have not been matched by new antifungal drugs and treatment still relies on old off-patent drugs: amphotericin B, flucytosine and fluconazole. Cryptococcal meningitis treatment is divided in three phases: induction, consolidation and maintenance. The induction phase, aimed at drastically reducing cerebrospinal fluid fungal burden, is key for patient survival. The major challenge in cryptococcal meningitis management has been the optimisation of induction phase treatment using the limited number of available medications, and major progress has recently been made. In this review, we summarise data from key trials which form the basis of current treatment recommendations for HIV-associated cryptococcal meningitis.
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boyerchammard2019recentf1000research Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Boyer-Chammard, Timothée;Temfack, Elvis;Alanio, Alexandre;Jarvis, Joseph N.;Harrison, Thomas S.;Lortholary, Olivier;
Journal F1000Research
Year 2019
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https://f1000research.com/articles/8-743/v1
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