Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial.

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2017
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Abstract
Saffron (.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. 60 participants finished the study. Patients who received either saffron or citalopram showed significant improvement in scores of the Hamilton Rating Scale for Depression (P-value<0.001 in both groups) and Hamilton Rating Scale for Anxiety (P-value<0.001 in both groups). Comparison of score changes between the 2 trial arms showed no significant difference (P-value=0.984). Frequency of side effects was not significantly different between the 2 groups. The present study indicates saffron as a potential efficacious and tolerable treatment for major depressive disorder with anxious distress.
Reference Key
ghajar2017crocuspharmacopsychiatry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ghajar, A;Neishabouri, S M;Velayati, N;Jahangard, L;Matinnia, N;Haghighi, M;Ghaleiha, A;Afarideh, M;Salimi, S;Meysamie, A;Akhondzadeh, S;
Journal pharmacopsychiatry
Year 2017
DOI
10.1055/s-0042-116159
URL
Keywords
depression saffron curcumin clinical trial antidepressant turmeric

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