Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans.

Clicks: 355
ID: 48876
2019
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Abstract
Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a defined consortium of human-gut-derived bacterial strains and fed different combinations of 34 food-grade fibers added to a representative low-fiber diet consumed in the United States. Bioactive carbohydrates in fiber preparations targeting particular Bacteroides species were identified using community-wide quantitative proteomic analyses of bacterial gene expression coupled with forward genetic screens. Deliberate manipulation of community membership combined with administration of retrievable artificial food particles, consisting of paramagnetic microscopic beads coated with dietary polysaccharides, disclosed the contributions of targeted species to fiber degradation. Our approach, including the use of bead-based biosensors, defines nutrient-harvesting strategies that underlie, as well as alleviate, competition between Bacteroides and control the selectivity of MDF components.
Reference Key
patnode2019interspeciescell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Patnode, Michael L;Beller, Zachary W;Han, Nathan D;Cheng, Jiye;Peters, Samantha L;Terrapon, Nicolas;Henrissat, Bernard;Le Gall, Sophie;Saulnier, Luc;Hayashi, David K;Meynier, Alexandra;Vinoy, Sophie;Giannone, Richard J;Hettich, Robert L;Gordon, Jeffrey I;
Journal Cell
Year 2019
DOI
S0092-8674(19)30899-2
URL
Keywords
community ecology biosensors interspecies competition microbiota-directed foods polysaccharide utilization

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