Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus.

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ID: 4873
2019
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Abstract
Card9 is a signaling adaptor protein in the downstream of many innate pattern recognition receptors(PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of Rhizopus arrhizus (R. arrhizus) using wild-type(WT) mice and Card9 knockout (Card9 ) mice to investigate the antifungal effect of Card9 against R. arrhizus infection. Card9 mice were more susceptible to R. arrhizus infection than WT mice, which could be related to the impaired NF-κB pathway activation, local cytokine production and Th cell responses in Card9 mice.
Reference Key
sun2019impairmentexperimental Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sun, Lingyue;Wan, Zhe;Li, Ruoyu;Yu, Jin;
Journal Experimental dermatology
Year 2019
DOI
10.1111/exd.14020
URL
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