Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus.

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ID: 4855
2009
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Ranked #18 of 34 articles by views in phytotherapy research : ptr

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Abstract
Several secondary metabolites, artemetin (1), casticin (2), 3,3'-dihydroxy-5,6,7,4'-tetramethoxy flavon (3), penduletin (4), methyl 4-hydroxybenzoate (5), p-hydroxybenzoic acid (6), methyl 3,4-dihydroxybenzoate (7), 5-hydroxy-2-methoxybenzoic acid (8), vanillic acid (9) and 3,4-dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, Vitex agnus-castus. The structures of compounds 1-10 were identified with the help of spectroscopic techniques. Compounds 3-10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell-based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition.
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choudhary2009antiinflammatoryphytotherapy Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Choudhary, M Iqbal;, ;Jalil, Saima;Nawaz, Sarfraz Ahmad;Khan, Khalid Mohammed;Tareen, Rasool Bakhsh;, ;
Journal phytotherapy research : ptr
Year 2009
DOI
10.1002/ptr.2639
URL
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