Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots.

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2019
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Abstract
The reversible volume transition of redox-responsive hydrogels by near-infrared (NIR) irradiation has recently attracted significant attention as a novel therapy matrix for tracking and treating cancer via stimuli-responsive fluorescence on/off with controllable volume transition via a wireless sensing system. Herein, a NIR-induced redox-sensitive hydrogel was synthesized by blending a hydrogel with IR825-loaded carbon dots (CD) to achieve enhanced mobility of nanoparticles inside a gel network, and reversible volume phase transitions remotely controlled by a smartphone application via the induction of different redox environments. The presence of CD-IR825 in the thermosensitive poly(N-isopropylacrylamide) hydrogel network imparted fluorescence, electronic and photothermal properties to the hydrogels, which resulted in volume shrinkage behavior of the hydrogel upon exposure to NIR laser irradiation due to the redox-sensitive CDs. Under the NIR on/off cycles, the photothermal temperature, fluorescence, and porous structure were reversed after turning off the NIR laser. The hydrogel responsiveness under GSH and NIR light was studied using a wireless device based on the changes in the resistance graph on a smartphone application, generating a fast and simple method for the investigation of hydrogel properties. The in vitro cell viabilities of the MDA-MB cancer cells incubated with the composite hydrogel in the presence of external GSH exhibited a higher photothermal temperature, and the cancer cells were effectively killed after the NIR irradiation. Therefore, the NIR-induced redox-responsive nanocomposite hydrogel prepared herein has potential for use in cancer treatment and will enable the study of nanoparticle motion in hydrogel networks under multiple stimuli via a wireless device using a faster and more convenient method.
Reference Key
phuong2019photothermalmodulatedbiomaterials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Phuong, Pham Thi My;Jhon, Heesauk;In, Insik;Park, Sung Young;
Journal Biomaterials science
Year 2019
DOI
10.1039/c9bm00734b
URL
Keywords
health care Wireless sensor networks Internet of Things authenticity cloud computing cryptography patient monitoring protocols computational cost doctors accurate operations computationally efficient mutual authentication protocol continuous operations cryptographic protocols existing protocol healthcare monitoring system incubator monitoring systems message authentication public key cryptography received information remote healthcare monitoring remote infant incubator monitoring system resource-limited sensors telecommunication security wireless medical sensor networks

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