Structure of human Vitronectin C-terminal domain and interaction with outer membrane protein Ail.

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ID: 47765
2019
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Abstract
Vitronectin (Vn) is a major component of blood that controls many processes central to human biology. It is a drug target and a key factor in cell and tissue engineering applications, but despite long-standing efforts, little is known about the molecular basis for its functions. Here, we define the domain organization of Vn, report the crystal structure of its carboxyl-terminal domain, and show that it harbors the binding site for the outer membrane protein Ail, which recruits Vn to the bacterial cell surface to evade human host defenses. Vn forms a single four-bladed β/α-propeller that serves as a hub for multiple functions. The structure explains key features of native Vn and provides a blueprint for understanding and targeting this essential human protein.
Reference Key
shin2019structurescience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shin, Kyungsoo;Lechtenberg, Bernhard C;Fujimoto, Lynn M;Yao, Yong;Bartra, Sara Schesser;Plano, Gregory V;Marassi, Francesca M;
Journal Science advances
Year 2019
DOI
10.1126/sciadv.aax5068
URL
Keywords
insulin disulfide bonds gold-coated copper oxide label-free sers oriented immobilization

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