Implications of Necroptosis for Cardiovascular Diseases.
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ID: 47616
2019
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Abstract
Necroptosis is a non-apoptotic programmed cell death pathway, which causes necrosis-like morphologic changes and triggers inflammation in the surrounding tissues. Accumulating evidence has demonstrated that necroptosis is involved in a number of pathological processes that lead to cardiovascular diseases. However, the exact molecular pathways linking them remain unknown. Herein, this review summarizes the necroptosis-related pathways involved in the development of various cardiovascular diseases, including atherosclerosis, cardiac ischemia-reperfusion injury, cardiac hypertrophy, dilated cardiomyopathy and myocardial infarction, and may shed light on the diagnosis and treatment of these diseases.
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| Reference Key |
ruan2019implicationscurrent
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| Authors | Ruan, Zhao-Hui;Xu, Zi-Xuan;Zhou, Xue-Yun;Zhang, Xian;Shang, Lei; |
| Journal | current medical science |
| Year | 2019 |
| DOI |
10.1007/s11596-019-2067-6
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