Mechanism of water dynamics in hyaluronic dermal fillers revealed by Nuclear Magnetic Resonance relaxometry.

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ID: 47431
2019
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Ranked #6 of 22 articles by views in Chemphyschem : a European journal of chemical physics and physical chemistry

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Abstract
1H spin-lattice Nuclear Magnetic Resonance relaxation experiment were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range from 4kHz to 40MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the scenarios of dynamics of water confined in the polymeric matrices were revealed. It was demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional (2D) character and the diffusion process is slower than diffusion in bulk water by 3-4 orders-of-magnitude. As far as rotational dynamics of the confined water is concerned, it was shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order-of-magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.
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kruk2019mechanismchemphyschem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kruk, Danuta;Rochowski, Pawel;Masiewicz, Elzbieta;Wilczynski, Slawomir;Wojciechowski, Milosz;Broche, Lionel;Lurie, David;
Journal Chemphyschem : a European journal of chemical physics and physical chemistry
Year 2019
DOI
10.1002/cphc.201900761
URL
Keywords
diffusion, relaxation, nuclear magnetic resonance, molecular dynamics, gels

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