Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids - highly potent antibacterial agents.

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ID: 47415
2012
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Ranked #214 of 406 articles by views in European journal of medicinal chemistry

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Abstract
An elegant and efficient synthesis of hitherto novel 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids has been accomplished for the first time in a green solvent viz. water. The hybrid molecules exhibit significant antibacterial activity when screened against four human pathogens viz. Streptococcus pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi. In comparison to the commercially marketed tetracycline, some of them were equally potent and a few more potent.
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sangaraiah2012facileeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sangaraiah, Nagarajan;Murugan, Sathishkumar;Poovan, Shanmugavelan;Raja, Ranganathan;Alagusundaram, Ponnuswamy;Ramakrishnan, Venkatesan;Vellasamy, Shanmugaiah;
Journal European journal of medicinal chemistry
Year 2012
DOI
10.1016/j.ejmech.2012.10.029
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