Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues.

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ID: 47068
2019
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Abstract
To understand the changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produce a multi-time point age-related gene expression signature (AGES) from liver, kidney, skeletal muscle, and hippocampus of rats, comparing 6-, 9-, 12-, 18-, 21-, 24-, and 27-month-old animals. We focus on genes that changed in one direction throughout the lifespan of the animal, either early in life (early logistic changes), at mid-age (mid-logistic), late in life (late-logistic), or linearly, throughout the lifespan of the animal. The pathways perturbed because of chronological age demonstrate organ-specific and more-global effects of aging and point to mechanisms that could potentially be counter-regulated pharmacologically to treat age-associated diseases. A small number of genes are regulated by aging in the same manner in every tissue, suggesting they may be more-universal markers of aging.
Reference Key
shavlakadze2019agerelatedcell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tea Shavlakadze, Melody Morris, Jian Fang, Sharon X Wang, Jiang Zhu, Weihua Zhou, Herman W Tse, Ricardo Mondragon-Gonzalez, Guglielmo Roma, David J Glass
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Journal Cell reports
Year 2019
DOI
S2211-1247(19)31091-5
URL
Keywords
inflammation gene expression aging kidney hippocampus rat mitochondria liver ageing rna-seq muscle aging gene signature

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