Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues.

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ID: 47068
2019
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Abstract
To understand the changes in gene expression that occur as a result of age, which might create a permissive or causal environment for age-related diseases, we produce a multi-time point age-related gene expression signature (AGES) from liver, kidney, skeletal muscle, and hippocampus of rats, comparing 6-, 9-, 12-, 18-, 21-, 24-, and 27-month-old animals. We focus on genes that changed in one direction throughout the lifespan of the animal, either early in life (early logistic changes), at mid-age (mid-logistic), late in life (late-logistic), or linearly, throughout the lifespan of the animal. The pathways perturbed because of chronological age demonstrate organ-specific and more-global effects of aging and point to mechanisms that could potentially be counter-regulated pharmacologically to treat age-associated diseases. A small number of genes are regulated by aging in the same manner in every tissue, suggesting they may be more-universal markers of aging.
Reference Key
shavlakadze2019agerelatedcell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shavlakadze, Tea;Morris, Melody;Fang, Jian;Wang, Sharon X;Zhu, Jiang;Zhou, Weihua;Tse, Herman W;Mondragon-Gonzalez, Ricardo;Roma, Guglielmo;Glass, David J;
Journal Cell reports
Year 2019
DOI
S2211-1247(19)31091-5
URL
Keywords
inflammation gene expression aging kidney hippocampus rat mitochondria liver ageing rna-seq muscle aging gene signature

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