Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice

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ID: 47027
2014
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Abstract
Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects. We investigated the anti-inflammatory effect of P. eryngii in mice with acute lung injury (ALI). Intranasal instillation of lipopolysaccharide (LPS) (10 μg/site/mouse) induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid) as well as histopathological damage in the lung, 6 h after treatment. Mice administered heat-treated P. eryngii (0.3–1 g/kg, p.o. (HTPE)) 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage. These results suggest that HTPE has anti-inflammatory effects against ALI. Thus, P. eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection.
Reference Key
kawai2014pleurotusevidencebased Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kawai, Junya;Andoh, Tsugunobu;Ouchi, Kenji;Inatomi, Satoshi;
Journal evidence-based complementary and alternative medicine
Year 2014
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2014/532389
Keywords
Medicine Biotechnology Science Agriculture (General) Other systems of medicine food processing and manufacture

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