Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover.

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ID: 46891
2019
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Abstract
Osteocytes play a critical role in mediating cell-cell communication and regulating bone homeostasis, and osteocyte apoptosis is associated with increased bone resorption. miR21, an oncogenic microRNA, regulates bone metabolism by acting directly on osteoblasts and osteoclasts, but its role in osteocytes is not clear. Here, we show that osteocytic miR21 deletion has sex-divergent effects in bone. In females, miR21 deletion reduces osteocyte viability, but suppresses bone turnover. Conversely, in males, miR21 deletion increases osteocyte viability, but stimulates bone turnover and enhances bone structure. Further, miR21 deletion differentially alters osteocyte cytokine production in the two sexes. Interestingly, despite these changes, miR21 deletion increases bone mechanical properties in both sexes, albeit to a greater extent in males. Collectively, our findings suggest that miR21 exerts both sex-divergent and sex-equivalent roles in osteocytes, regulating osteocyte viability and altering bone metabolism through paracrine actions on osteoblasts and osteoclasts differentially in males vs. females, whereas, influencing bone mechanical properties independent of sex.
Reference Key
davis2019osteocyticthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Davis, Hannah M;Deosthale, Padmini J;Pacheco-Costa, Rafael;Essex, Alyson L;Atkinson, Emily G;Aref, Mohammad W;Dilley, Julian E;Bellido, Teresita;Mircea, Ivan;Allen, Matthew;Plotkin, Lilian I;
Journal The FEBS Journal
Year 2019
DOI
10.1111/febs.15066
URL
Keywords
Bone cytokine microrna apoptosis mir21 osteocyte sexual-dimorphism

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