Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer.
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ID: 46881
2019
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Abstract
Dysregulation of lipid metabolism is common in cancer. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been implicated with various cancer types. Here we analyzed by immunohistochemistry its expression in 2,197 breast cancers. LPCAT1 staining was found in 97.8% of 1,774 interpretable tumors, including 48.1% with weak, 28.7% with moderate, and 14.4% with strong expression. The frequency of LPCAT1 positivity depended on the histological tumor type. Moderate or strong LPCAT1 positivity was more common in cancers of no special type (NST) (46.2%) than in lobular carcinomas (25.9%; p<0.0001). Strong LPCAT1 was associated with BRE grade, tumor cell proliferation and overall survival in all cancers and in the subgroup of NST cancers (p<0.0001, each). In the subset of NST cancers the prognostic effect of LPCAT1 expression was independent of pT, and BRE grade (p<0.0001 each). A comparison with molecular features showed that LPCAT1 was strongly associated with estrogen receptor negativity (p<0.0001), progesterone receptor negativity (p<0,0001), amplification of HER2 (p<0.0001) and MYC (p=0.0066), as well as deletions of PTEN (p<0.0001) and CDKNA2 (p=0.0151). It is concluded that LPCAT1 overexpression is linked to adverse tumor features and poor prognosis in breast cancer. These data also highlight the important role of lipid metabolism in breast cancer biology.
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| Reference Key |
lebok2019upregulationaging
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| Authors | Lebok, Patrick;von Hassel, Aurelia;Meiners, Jan;Hube-Magg, Claudia;Simon, Ronald;Höflmayer, Doris;Hinsch, Andrea;Dum, David;Fraune, Christoph;Göbel, Cosima;Möller, Katharina;Sauter, Guido;Jacobsen, Frank;Büscheck, Franziska;Prien, Kristina;Krech, Till;Krech, Rainer Horst;von der Assen, Albert;Wölber, Linn;Witzel, Isabell;Schmalfeldt, Barbara;Geist, Stefan;Paluchoswski, Peter;Wilke, Christian;Heilenkötter, Uwe;Terracciano, Luigi;Müller, Volkmar;Wilczak, Waldemar;Burandt, Eike Christian; |
| Journal | Aging |
| Year | 2019 |
| DOI |
10.18632/aging.102287
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