Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects

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ID: 4665
1970
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Abstract
Two new terpene glycosides (1–2) along with two known analogs (3–4) were obtained from the root of Sanguisorba officinalis, which is a common traditional Chinese medicine (TCM). Their structures were elucidated by nuclear magnetic resonance (NMR), electrospray ionization high resolution mass spectrometry (HRESIMS), and a hydrolysis reaction, as well as comparison of these data with the literature data. Compounds 1–4 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). An anti-inflammatory assay based on the zebrafish experimental platform indicated that compound 1 had good anti-inflammatory activity in vivo by not only regulating the distribution, but also by reducing the amount of the macrophages of the zebrafish exposed to copper sulfate.
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dale1970terpenemolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Da-Le Guo;Jin-Feng Chen;Lu Tan;Meng-Ying Jin;Feng Ju;Zhi-Xing Cao;Fang Deng;Li-Na Wang;Yu-Cheng Gu;Yun Deng;Guo, Da-Le;Chen, Jin-Feng;Tan, Lu;Jin, Meng-Ying;Ju, Feng;Cao, Zhi-Xing;Deng, Fang;Wang, Li-Na;Gu, Yu-Cheng;Deng, Yun and
Journal molecules
Year 1970
DOI
10.3390/molecules24162906
URL
Keywords Keywords not found

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