[Clinical challenges and implications of intratumor heterogeneity].

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Ranked #4 of 12 articles by views in revista espanola de patologia : publicacion oficial de la sociedad espanola de anatomia patologica y de la sociedad espanola de citologia

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Abstract
Tumors display a high, albeit variable, grade of intratumor heterogeneity, both from a clinical and a morphological viewpoint. Furthermore, recent methods of large-scale molecular analysis demonstrate to what extent tumors can also be heterogeneous from a molecular perspective. This is of paramount importance for patients as it has a great impact on the success of so-called precision therapies and explains the reason for a significant number of therapeutic failures in modern oncology. We present an up-to-date review of the latest findings in a group of tumors with a high social impact, commonly seen in the daily routine of the pathology laboratory.
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palaciosclinicalrevista Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Palacios, José;Matías-Guiu, Xavier;Rodríguez-Peralto, Jose Luis;de Álava, Enrique;López, José Ignacio;
Journal revista espanola de patologia : publicacion oficial de la sociedad espanola de anatomia patologica y de la sociedad espanola de citologia
Year Year not found
DOI
S1699-8855(19)30045-5
URL
Keywords
Breast cancer melanoma molecular pathology intratumor heterogeneity sarcoma adenocarcinoma de endometrio carcinoma de mama carcinoma renal de células claras clear cell renal cell carcinoma endometrial adenocarcinoma heterogeneidad intratumoral patología molecular sarcomas

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