Epithelioid hemangioendothelioma of the parotid gland: A case report in an unusual location with a review of the literature.

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Abstract
Epithelioid hemangioendothelioma (EHE) is a malignant vascular tumor that usually affects the liver, lung, bone and deep soft tissues of the extremities or trunk. To our knowledge, only 3 cases in the parotid gland have been reported to date. We report a case of a 62-year-old woman who presented with a 1-year history of a slow-growing, painless mass over the left mandibular angle. Imaging studies showed a 2cm mass over the left parotid gland with peripheral calcifications. The patient underwent a superficial parotidectomy. Sections displayed neoplastic epithelioid cells with cytoplasmic vacuoles containing erythrocytes, surrounded by a myxohyaline stroma. Immunohistochemistry was positive for CD31, CD34, ERG, and factor VIII, but negative for cytokeratin AE1/AE3, CK7, EMA, SMA, and S100. The findings were those of an EHE involving the parotid gland. This case demonstrates an EHE in a rare location and emphasizes the need to consider this tumor when diagnosing uncommon soft tissue tumors of salivary glands.
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Authors Suarez-Zamora, David A;Rodriguez-Urrego, Paula A;Hakim-Tawil, Jose A;Palau-Lazaro, Mauricio A;
Journal revista espanola de patologia : publicacion oficial de la sociedad espanola de anatomia patologica y de la sociedad espanola de citologia
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DOI
S1699-8855(19)30043-1
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