Physical determinants of cell organization in soft media.

Clicks: 368
ID: 46577
2005
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Abstract
Cell adhesion is an integral part of many physiological processes in tissues, including development, tissue maintenance, angiogenesis, and wound healing. Recent advances in materials science (including microcontact printing, soft lithography, microfluidics, and nanotechnology) have led to strongly improved control of extracellular ligand distribution and of the properties of the micromechanical environment. As a result, the investigation of cellular response to the physical properties of adhesive surfaces has become a very active area of research. Sophisticated use of elastic substrates has revealed that cell organization in soft media is determined by active mechanosensing at cell-matrix adhesions. In order to determine the underlying mechanisms, quantification and biophysical modelling are essential. In tissue engineering, theory might help to design new environments for cells.
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schwarz2005physicalmedical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Schwarz, Ulrich S;Bischofs, Ilka B;
Journal medical engineering & physics
Year 2005
DOI
DOI not found
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Keywords
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