Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors

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ID: 4657
1970
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Abstract
A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.
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dorota1970diselenidesmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dorota Krasowska;Nunzio Iraci;Claudio Santi;Józef Drabowicz;Marcin Cieslak;Julia Kaźmierczak-Barańska;Martina Palomba;Karolina Królewska-Golińska;Jakub Magiera;Luca Sancineto;Krasowska, Dorota;Iraci, Nunzio;Santi, Claudio;Drabowicz, Józef;Cieslak, Marcin;Kaźmierczak-Barańska, Julia;Palomba, Martina;Królewska-Golińska, Karolina;Magiera, Jakub;Sancineto, Luca and
Journal molecules
Year 1970
DOI
10.3390/molecules24162914
URL
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