A new hybrid double divisor ratio spectra method for the analysis of ternary mixtures.

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ID: 45994
2008
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Abstract
A new spectrophotometric method was developed for the simultaneous determination of ternary mixtures, without prior separation steps. This method is based on convolution of the double divisor ratio spectra, obtained by dividing the absorption spectrum of the ternary mixture by a standard spectrum of two of the three compounds in the mixture, using combined trigonometric Fourier functions. The magnitude of the Fourier function coefficients, at either maximum or minimum points, is related to the concentration of each drug in the mixture. The mathematical explanation of the procedure is illustrated. The method was applied for the assay of a model mixture consisting of isoniazid (ISN), rifampicin (RIF) and pyrazinamide (PYZ) in synthetic mixtures, commercial tablets and human urine samples. The developed method was compared with the double divisor ratio spectra derivative method (DDRD) and derivative ratio spectra-zero-crossing method (DRSZ). Linearity, validation, accuracy, precision, limits of detection, limits of quantitation, and other aspects of analytical validation are included in the text.
Reference Key
youssef2008aspectrochimica Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Youssef, Rasha M;Maher, Hadir M;
Journal spectrochimica acta part a, molecular and biomolecular spectroscopy
Year 2008
DOI
DOI not found
URL URL not found
Keywords
spectrophotometry atorvastatin ezetimibe dual wavelength method mean centering of ratio spectra

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