Psyllium ( Forsk) Husk Powder as a Natural Superdisintegrant for Orodispersible Formulations: A Study on Meloxicam Tablets.

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ID: 44775
2019
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Abstract
(1) Background: In this work, we investigated the application of a natural superdisintegrant, psyllium ( Forsk) husk powder, for the manufacture of orodispersible meloxicam tablets. Meloxicam was chosen as a model compound for the study. (2) Methods: The tablets were prepared using different concentrations of psyllium husk by direct compression. Bulk density, tapped density, hardness, friability, disintegration, and dissolution time tests were used to assess the quality of the formulations. (3) Results: Psyllium husk powder significantly increased the dissolution rate of meloxicam. The formulation containing 16 mg of psyllium husk powder showed the lowest wetting time, the highest water absorption ratio, and the lowest disintegration time compared to the control and to the other formulations. These effects may be attributed to the rapid uptake of water due to the vigorous swelling ability of psyllium husk powder. (4) Conclusions: The powder could be recommended as an effective natural superdisintegrant for orodispersible formulations.
Reference Key
draksiene2019psylliummolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Draksiene, Gailute;Kopustinskiene, Dalia M;Lazauskas, Robertas;Bernatoniene, Jurga;
Journal molecules
Year 2019
DOI
E3255
URL
Keywords
disintegrant dissolution rate in vitro release meloxicam orodispersible tablets psyllium husk powder risk communication bibliometrics vosviewer citespace scientometrics

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