Synthesis and Physicochemical Characterization of Mesoporous SiO2 Nanoparticles
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2014
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Abstract
There exists a knowledge gap in understanding potential toxicity of mesoporous silica nanoparticles. A critical step in assessing toxicity of these particles is to have a wide size range with different chemistries and physicochemical properties. There are several challenges when synthesizing mesoporous silica nanoparticles over a wide range of sizes including (1) nonuniform synthesis protocols using the same starting materials, (2) the low material yield in a single batch synthesis (especially for particles below 60–70 nm), and (3) morphological instability during surfactant removal process and surface modifications. In this study, we synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm. Surfaces of the silica nanoparticles were modified with hydrophilic-CH2–(CH2)2–COOH and relatively hydrophobic-CH2–(CH2)10–COOH functional groups. All silica nanoparticles were analysed for morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media. Our analysis revealed the synthesis of a spectrum of monodisperse bare and surface modified mesoporous silica nanoparticles with a narrow particle size distribution and devoid of cocontaminants critical for toxicity studies. Complete physicochemical characterization of these synthetic mesoporous silica nanoparticles will permit systematic toxicology studies for investigation of structure-activity relationships.
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das2014synthesisjournal
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| Authors | Das, Dharani;Yang, Yong;O’Brien, Julie S.;Breznan, Dalibor;Nimesh, Surendra;Bernatchez, Stéphane;Hill, Myriam;Sayari, Abdelhamid;Vincent, Renaud;Kumarathasan, Prem; |
| Journal | journal of nanomaterials |
| Year | 2014 |
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| Keywords | Keywords not found |
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