Bioinspired photonic barcodes for multiplexed target cycling and hybridization chain reaction.

Clicks: 379
ID: 44292
2019
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Abstract
Multiplexed detection of microRNA (miRNA) is of great value in clinical diagnosis. Here, a new type of polydopamine (PDA) encapsulated photonic crystal (PhC) barcodes are employed for target-triggering cycle amplification and hybridization chain reaction (HCR) to achieve multiplex miRNA quantification. The PDA-decorated PhC barcodes not only exhibit distinctive structural color for different encoding miRNAs, they also can immobilize biomolecules, allowing subsequent reaction with amino-modified hairpin probes (H1). When the PDA-decorated PhC barcodes are used in assays, target miRNAs can be circularly used to initiate HCR for cycle amplification. Therefore, by tuning the structural colors of the PDA-integrated PhC, the multiplexed miRNA quantification could be realized. We demonstrate that our strategy for multiplexed detection of miRNA is reasonably accurate, reliable and repeatable, with a detection limit as low as 8.0 fM. Our results show that PDA encapsulated PhC barcodes as a novel platform offer a pathway toward the multiplex analysis of low-abundance biomarkers for biomedical assays.
Reference Key
zhang2019bioinspiredbiosensors Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Dagan;Bian, Feika;Cai, Lijun;Wang, Tianfu;Kong, Tiantian;Zhao, Yuanjin;
Journal Biosensors & bioelectronics
Year 2019
DOI
S0956-5663(19)30708-0
URL
Keywords
mirna barcode polydopamine colloidal crystal target cycle amplification

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