Pulmonary Valve Function Late after Ross procedure in 443 adult patients.

Função da valva pulmonar tardia após o procedimento de Ross em 443 pacientes adultos.

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ID: 43721
2019
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Abstract
Limited data exists on long-term pulmonary valve function after the Ross procedure. This study sought to determine the long-term function of the pulmonary valve in 443 consecutive adult patients who underwent a Ross procedure.All 443 patients who underwent a Ross procedure between November 1992 and March 2018 were reviewed retrospectively. All underwent pulmonary valve replacement using a cryopreserved pulmonary allograft. Freedom from the study's outcomes were calculated using Kaplan Meier survival. Risk factors for valve failure were analyzed using Cox regression.Mean age at time of operation was 39 years (range 15-66 years). There was 1 (0.2%, 1/443) operative mortality. Nine patients required reintervention on the pulmonary allograft at a mean 6.1 years (range 1-12 years) after Ross procedure. Patients required pulmonary allograft reintervention for infective endocarditis (n=4), severe pulmonary stenosis (n=4) or severe pulmonary regurgitation (PR) (n=1). Freedom from pulmonary allograft reintervention was 98.9% (95%CI 97.1-99.6), 97.7% (95%CI 95.1-98.9), 96.6% (95%CI 93.3-98.3) and 96.6% (95%CI 93.3-98.3) at 5, 10, 15 and 20 years (Figure 1). Freedom from pulmonary allograft dysfunction (at least moderate PR and/or mean systolic gradient ≥ 25mmHg and/or reintervention) was 94.5% (95%CI 91.6-96.4), 88.1% (95%CI 83.6-91.4), 84.9% (95%CI 79.6-88.9) and 78.3% (95%CI 69.5-84.9) at 5, 10, 15 and 20 years. No risk factors were identified to influence pulmonary valve durability.The pulmonary valve allograft gives excellent long-term function when used in adults undergoing the Ross procedure. Reintervention on the pulmonary valve is rare and significant pulmonary allograft dysfunction is uncommon.
Existem dados limitados sobre a função da valva pulmonar a longo prazo após o procedimento de Ross. Este estudo teve como objetivo determinar a função a longo prazo da valva pulmonar em 443 pacientes adultos consecutivos submetidos ao procedimento de Ross. Todos os 443 pacientes submetidos ao procedimento de Ross entre novembro de 1992 e março de 2018 foram analisados retrospectivamente. Todos foram submetidos à substituição da valva pulmonar utilizando um aloenxerto pulmonar criopreservado. As taxas de sobrevida livre dos desfechos do estudo foram calculadas pelo método de Kaplan-Meier. Os fatores de risco para falência valvar foram analisados por meio de regressão de Cox. A média de idade no momento da cirurgia foi de 39 anos (variação de 15 a 66 anos). Houve 1 (0,2%, 1/443) óbito operatório. Nove pacientes necessitaram de reintervenção no aloenxerto pulmonar em uma média de 6,1 anos (variação de 1 a 12 anos) após o procedimento de Ross. Os pacientes necessitaram de reintervenção no aloenxerto pulmonar por endocardite infecciosa (n=4), estenose pulmonar grave (n=4) ou regurgitação pulmonar (RP) grave (n=1). A sobrevida livre de reintervenção no aloenxerto pulmonar foi de 98,9% (IC 95% 97,1-99,6), 97,7% (IC 95% 95,1-98,9), 96,6% (IC 95% 93,3-98,3) e 96,6% (IC 95% 93,3-98,3) aos 5, 10, 15 e 20 anos (Figura 1). A sobrevida livre de disfunção do aloenxerto pulmonar (RP pelo menos moderada e/ou gradiente sistólico médio ≥ 25 mmHg e/ou reintervenção) foi de 94,5% (IC 95% 91,6-96,4), 88,1% (IC 95% 83,6-91,4), 84,9% (IC 95% 79,6-88,9) e 78,3% (IC 95% 69,5-84,9) aos 5, 10, 15 e 20 anos. Não foram identificados fatores de risco que influenciassem a durabilidade da valva pulmonar. O aloenxerto valvar pulmonar proporciona excelente função a longo prazo quando utilizado em adultos submetidos ao procedimento de Ross. A reintervenção na valva pulmonar é rara, e a disfunção significativa do aloenxerto pulmonar é incomum.
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Authors Fricke, Tyson A;Skillington, Peter D;Shi, William;Buratto, Edward;Wynne, Rochelle;Larobina, Marco;Grigg, Leeanne;
Journal the annals of thoracic surgery
Year 2019
DOI
S0003-4975(19)31349-9
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