Effects of noninvasive brain stimulation on language networks and recovery in early poststroke aphasia.

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ID: 43405
2013
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Abstract
Modulation of activity in language networks using repetitive transcranial magnetic stimulation (rTMS) may possibly support recovery from poststroke aphasia. Case series and feasibility studies seem to indicate a therapeutic effect; however, randomized sham-controlled, proof-of-principle studies relating clinical effects to activation patterns are missing.Twenty-four patients with subacute poststroke aphasia were randomized to a 10-day protocol of 20-minute inhibitory 1 Hz rTMS over the right triangular part of the posterior inferior frontal gyrus or sham stimulation, followed by 45 minutes of speech and language therapy. Activity in language networks was measured with O-15-water positron emission tomography during verb generation before and after treatment. Language performance was assessed using the Aachen Aphasia Test battery.The primary outcome measure, global Aachen Aphasia Test score change, was significantly higher in the rTMS group (t test, P=0.003). Increases were largest for subtest naming (P=0.002) and tended to be higher for comprehension, token test, and writing (P<0.1). Patients in the rTMS group activated proportionally more voxels in the left hemisphere after treatment than before (difference in activation volume index) compared with sham-treated patients (t test, P=0.002).There was a moderate but significant linear relationship between activation volume index change and global Aachen Aphasia Test score change (r2=0.25; P=0.015).Ten sessions of inhibitory rTMS over the right posterior inferior frontal gyrus, in combination with speech and language therapy, significantly improve language recovery in subacute ischemic stroke and favor recruitment of left-hemispheric language networks.
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thiel2013effectsstroke Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thiel, Alexander;Hartmann, Alexander;Rubi-Fessen, Ilona;Anglade, Carole;Kracht, Lutz;Weiduschat, Nora;Kessler, Josef;Rommel, Thomas;Heiss, Wolf-Dieter;
Journal Stroke
Year 2013
DOI
10.1161/STROKEAHA.111.000574
URL
Keywords
stroke treatment recovery plasticity transcranial magnetic stimulation

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