A novel signal-amplified electrochemical aptasensor based on supersandwich G-quadruplex DNAzyme for highly sensitive cancer cell detection
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ID: 43053
2015
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Abstract
A novel electrochemical biosensor for cancer cell detection was developed based on aptamer-based competition and supersandwich G-quadruplex DNAzyme amplification strategy. Due to the stronger affinity between the aptamer and cancer cells than that with its complementary oligonucleotide, the complementary oligonucleotide will be facilely replaced. As a consequence, we can detect cancer cells indirectly by detecting the releasing DNA which is proportional to the concentration of K562 cells. Through the supersandwich G-quadruplex DNAzyme amplification strategy, the sensitivity can be dramatically enhanced with detection limit down to 14 cells. Keywords: Signal-amplified, Supersandwich, G-quadruplex DNAzyme, Cancer cell
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| Reference Key |
lu2015aelectrochemistry
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|---|---|
| Authors | Lu, Cai-Yu;Xu, Jing-Juan;Wang, Zong-Hua;Chen, Hong-Yuan; |
| Journal | electrochemistry communications |
| Year | 2015 |
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