An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell

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ID: 43052
2012
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Ranked #270 of 430 articles by views in International journal of molecular sciences

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Abstract
This paper reports a method for electrical communication between the inner part of cells and an electrode with the help of iRGD peptide. Due to the enhancement of the cell penetration caused by iRGD peptide, DNA molecules, previously modified on a gold electrode surface, can be easily transfected into the cells. At the same time, doxorubicin, an anticancer drug, can also be transfected into cells with high penetration. Consequently, doxorubicin binds to DNA chains through electrostatic interaction, and the redox reaction is transferred out of the cell across the cell membrane. As a result, this work may provide a novel way to get information from inside of cells. <strong></strong>
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li2012aninternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
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Journal International journal of molecular sciences
Year 2012
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