Framework Nucleic Acid-Enabled Programming of Electrochemical Catalytic Properties of Artificial Enzymes.

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ID: 43025
2019
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Abstract
The creation and engineering of artificial enzymes remain a challenge, especially the arrangement of enzymes into geometric patterns with nanometer precision. In this work, we fabricated a series of novel DNA-tetrahedron-scaffolded-DNAzymes (Tetrazymes) and evaluated the catalytic activity of these Tetrazymes by electrochemistry. Tetrazymes were constructed by precisely positioning G-quadruplex on different sites of a DNA tetrahedral framework, with hemin employed as the co-catalyst. Immobilization of Tetrazymes on a gold electrode surface revealed horseradish peroxidase (HPR)-mimicking bioelectrocatalytic property. Cyclic voltammogram and amperometry were employed to evaluate the capability of Tetrazymes of different configurations to electrocatalyze the reduction of hydrogen peroxide (HO). These artificial Tetrazymes displayed 6- to 14-fold higher enzymatic activity than G-quadruplex/hemin (G4-hemin) without the DNA tetrahedron scaffold, demonstrating application potential in developing novel G-quadruplex-based electrochemical sensors.
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zeng2019frameworkacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zeng, Dongdong;San, Lili;Qian, Fengyu;Ge, Zhilei;Xu, Xiaohui;Wang, Bin;Li, Qian;He, Guifang;Mi, Xianqiang;
Journal ACS applied materials & interfaces
Year 2019
DOI
10.1021/acsami.9b06480
URL
Keywords
enzymatic activity electrochemistry dna tetrahedral nanostructure g-quadruplex framework nucleic acid

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