Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(i) complex.

Clicks: 439
ID: 42708
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #11 of 324 articles by views in Dalton transactions (Cambridge, England : 2003)

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 324 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Lysosomes play a critical role in the autophagy process. The impairment of lysosomes can affect the degradation of autophagic cargo, leading to the blockage of autophagy at the lysosomal stage and subsequent cell death. Herein, two phosphorescent Re(i) tricarbonyl complexes (Re1 and Re2) bearing β-carboline derivatives have been synthesized and characterized. Both complexes show pH-dependent phosphorescence, which can be used to specifically image the lysosomes. Cytotoxicity assay shows that they exhibit high anticancer activity and are able to overcome cross-resistance to cisplatin. Re2 can induce autophagy, which is blocked at the lysosomal stage due to lysosomal dysfunction, such as the decrease of cathepsin B activity, subsequently leading to both autophagy and apoptosis dependent cell death. In vivo studies revealed that it could significantly inhibit tumor growth.
Reference Key
he2019impairmentdalton Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors He, Liang;Pan, Zheng-Yin;Qin, Wei-Wei;Li, Yi;Tan, Cai-Ping;Mao, Zong-Wan;
Journal Dalton transactions (Cambridge, England : 2003)
Year 2019
DOI
10.1039/c9dt00322c
URL
Keywords
oxidation copper heterocycles radicals pi interactions

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.