Effect of oblique polymer pillars on spreading and elongation of rat mesenchymal stem cells.

Clicks: 191
ID: 42368
2019
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Abstract
Stiffness and anisotropy of culture substrates are important factors influencing the cell behavior and their responses to external stimuli. Herein, we report a fabrication method of oblique polymer pillars which allow modulating both stiffness and anisotropy of the substrate for spreading and elongation studies of Rat Mesenchymal Stem Cells (RMSCs). Poly (Lactic-co-Glycolic Acid) (PLGA) has been chosen to produce micro-pillars of different heights and different pitches using a combined method of soft-lithography and hot embossing. The stiffness of such pillar substrates varies over a large range so that RMSCs show effectively different spreading behaviors which are also sensitive to the inclining angle of the pillars. Our results showed that with the increase of the pillar height the area of cell spreading decreases but the cell elongation aspect ratio increases. Moreover, cells preferentially elongate along the direction perpendicular to that of the pillars' inclining, which is in agreement with the calculated anisotropy of the pillar substrate stiffness.
Reference Key
hu2019effectcolloids Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hu, Jie;Liu, Yan-Jun;Shi, Jian;Wang, Li;Piel, Matthieu;Chen, Yong;
Journal colloids and surfaces b, biointerfaces
Year 2019
DOI
S0927-7765(19)30629-0
URL
Keywords Keywords not found

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