Preliminary evidence from planarians that cotinine establishes a conditioned place preference.

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ID: 4233
2019
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Abstract
While the psychoactive stimulant nicotine has been the subject of extensive research, considerably less attention has focused on other compounds found in either tobacco smoke or that are nicotine metabolites. Recent papers have suggested that some of the compounds in question may either alter nicotine's effects or have reinforcing properties themselves, although they would only be experienced after consumption of tobacco. The potential for these compounds to function as reinforcers or to potentiate the reinforcing properties of nicotine merits investigation. To pursue this line of inquiry, we examined cotinine in a planarian model of environmental place preference. In the present study, planarians demonstrated that the compound cotinine, which is present in tobacco smoke, and is also the principal nicotine metabolite, establishes a conditioned place preference. These data represent the first ever demonstration that cotinine will establish a conditioned place preference in planarians and possibly contribute to the addictive properties of nicotine.
Reference Key
phelps2019preliminaryneuroscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Phelps, Brady J;Miller, Tyler M;Arens, Heath;Hutchinson, Tayler;Lang, Kaitlyn A;Muckey, Linda M;Thompson, Nicholas;Stanage, Steven;Rahman, Shafiqur;Rawls, Scott M;
Journal neuroscience letters
Year 2019
DOI
S0304-3940(19)30180-6
URL
Keywords Keywords not found

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