Predator odor produces anxiety-like behavioral phenotype in planarians that is counteracted by fluoxetine.

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ID: 4231
2019
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Abstract
Avoidant behavior is a characteristic feature post-traumatic stress disorder (PTSD) and is modeled in mammals with predator odor. Light avoidance is a hallmark behavioral reaction in planarians. We hypothesized that planarians exposed to frog extract would display enhanced light avoidance that is prevented by fluoxetine. Enhanced light avoidance (i.e., less time spent in light compartment of a dish split into light and dark sides) after a 30-min frog extract exposure (0.0001-0.01%) manifested 15 min post-exposure, persisted for at least 24 h, and was counteracted by fluoxetine (10 μM). These results suggest conservation of an anxiety-like behavioral phenotype.
Reference Key
cho2019predatorphysiology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cho, M;Nayak, Sunil U;Jennings, T;Tallarida, Christopher S;Rawls, Scott M;
Journal physiology & behavior
Year 2019
DOI
S0031-9384(19)30167-2
URL
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