Large-scale ensemble simulations of biomathematical brain arteriovenous malformation models using graphics processing unit computation.

Clicks: 167
ID: 41480
2019
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Abstract
Theoretical modeling allows investigations of cerebral arteriovenous malformation (AVM) hemodynamics, but current models are too simple and not clinically representative. We developed a more realistic AVM model based on graphics processing unit (GPU) computing, to replicate highly variable and complex nidus angioarchitectures with vessel counts in the thousands-orders of magnitude greater than current models.We constructed a theoretical electrical circuit AVM model with a nidus described by a stochastic block model (SBM) of 57 nodes and an average of 1000 plexiform and fistulous vessels. We sampled and individually simulated 10,000 distinct nidus morphologies from this SBM, constituting an ensemble simulation. We assigned appropriate biophysical values to all model vessels, and known values of mean intravascular pressure (P) to extranidal vessels. We then used network analysis to calculate P and volumetric flow rate within each nidus vessel, and mapped these values onto a graphic representation of the nidus network. We derived an expression for nidus rupture risk and conducted a model parameter sensitivity analysis.Simulations revealed a total intranidal volumetric blood flow ranging from 268 mL/min to 535 mL/min, with an average of 463 mL/min. The maximum percentage rupture risk among all vessels in the nidus ranged from 0% to 60%, with an average of 29%.This easy to implement biomathematical AVM model, allowed by parallel data processing using advanced GPU computing, will serve as a useful tool for theoretical investigations of AVM therapies and their hemodynamic sequelae.
Reference Key
jain2019largescalecomputers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jain, Mika S;Do, Huy M;Wintermark, Max;Massoud, Tarik F;
Journal Computers in biology and medicine
Year 2019
DOI
S0010-4825(19)30293-8
URL
Keywords Keywords not found

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