Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish ().

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ID: 41414
2019
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Abstract
The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish.
Reference Key
kim2019riceinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Yu-Mi;Lee, Eun-Cheol;Lim, Han-Moi;Seo, Young-Kwon;
Journal International journal of molecular sciences
Year 2019
DOI
E2172
URL
Keywords Keywords not found

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