Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates

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2015
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Abstract
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata, a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro, notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies.
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denardi2015synergisticbrazilian Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Denardi, Laura Bedin;Mario, Débora Alves Nunes;Loreto, Érico Silva;Santurio, Janio Morais;Alves, Sydney Hartz;
Journal brazilian journal of microbiology
Year 2015
DOI
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URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000100125&lng=en&tlng=en
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