Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-]pyrazole tethered carbohydrazide hybrids: exploring their ADMET, ergosterol inhibition and ROS inducing potential.

Clicks: 596
ID: 4044
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #1 of 44 articles by views in medchemcomm

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
A series of new 1,4-dihydroindeno[1,2-]pyrazole tethered carbohydrazide hybrids () were designed, synthesized and evaluated for their antimicrobial activity. Compounds , , , and demonstrated significant activity against the entire panel of test pathogens. Further, compounds and exhibited significant anti- activity. These potential hybrids ( and ) also exhibited promising ergosterol biosynthesis inhibition against , which was further validated through molecular docking studies. Furthermore, compounds and caused intracellular ROS accumulation in MTCC 3017 and were non-toxic to normal human lung cell line MRC5. studies revealed that they demonstrated drug likeness and an appreciable pharmacokinetic profile. Overall, the findings demonstrate that and may be considered as promising leads for further development of new antifungal drugs.
Reference Key
shareef2019designmedchemcomm Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shareef, Mohd Adil;Sirisha, K;Khan, Irfan;Sayeed, Ibrahim Bin;Jadav, Surender Singh;Ramu, Gopathi;Kumar, C Ganesh;Kamal, Ahmed;Babu, Bathini Nagendra;
Journal medchemcomm
Year 2019
DOI
10.1039/c9md00155g
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.