Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling?

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ID: 4035
2019
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Ranked #1 of 43 articles by views in cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

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Abstract
Estrogen could play a key role in the mechanisms underlying sex-related disparity in the incidence of thrombotic events. We investigated whether estrogen receptors (ERs) were expressed in human red blood cells (RBCs), and if they affected cell signaling of erythrocyte constitutive isoform of endothelial NO-synthase (eNOS) and nitric oxide (NO) release.RBCs from 29 non-smoker volunteers (15 males and 14 females) aged between 20 and 40 years were analyzed by cytometry and western blot. In particular, content and distribution of ER-α and ER-β, tyrosine kinases and eNOS phosphorylation and NO release were analyzed.We demonstrated that: i) both ER-α and ER-β were expressed by RBCs; ii) they were both functionally active; and iii) ERs distribution and function were different in males and females. In particular, ERs modulated eNOS phosphorylation and NO release in RBCs from both sexes, but they induced the phosphorylation of specific tyrosine residues of kinases linked to eNOS activation and NO release in the RBCs from females only.Collectively, these data suggest that ERs could play a critical role in RBC intracellular signaling. The possible implication of this signaling in sex-linked risk disparity in human cardiovascular diseases, e.g. in thrombotic events, may not be ruled out.
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vona2019functionalcellular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Vona, Rosa;Gambardella, Lucrezia;Ortona, Elena;Santulli, Maria;Malorni, Walter;Carè, Alessandra;Pietraforte, Donatella;Straface, Elisabetta;
Journal cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Year 2019
DOI
10.33594/000000129
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