Hybrid cis-stilbene Molecules: Novel Anticancer Agents

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ID: 4027
2019
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Abstract
The growing interest in anticancer hybrids in the last few years has resulted in a great number of reports on hybrid design, synthesis and bioevaluation. Many novel multi-target-directed drug candidates were synthesized, and their biological activities were evaluated. For the design of anticancer hybrid compounds, the molecules of stilbenes, aromatic quinones, and heterocycles (benzimidazole, imidazole, pyrimidine, pyridine, pyrazole, quinoline, quinazoline) were applied. A distinct group of hybrids comprises the molecules built with natural compounds: Resveratrol, curcumin, coumarin, and oleanolic acid. In this review, we present the studies on bioactive hybrid molecules of a well-known tubulin polymerization inhibitor, combretastatin A-4 and its analogs with other pharmacologically active entities. The mechanism of anticancer activity of selected hybrids is discussed considering the structure-activity relationship.
Reference Key
piekusomka2019hybridinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Piekuś-Słomka, Natalia;Mikstacka, Renata;Ronowicz, Joanna;Sobiak, Stanisław;
Journal International journal of molecular sciences
Year 2019
DOI
DOI not found
URL
http://www.mdpi.com/1422-0067/20/6/1300
Keywords Keywords not found

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