The Mononuclear Phagocytic System. Generation of Diversity.

Clicks: 17
ID: 39992
2019
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Ranked #109 of 111 articles by views in Frontiers in immunology

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Abstract
We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diversity remains incomplete, nor is the mechanism of diversification understood. In this essay we review some of the implications of what we know, and draw attention to issues to be clarified in further research, taking advantage of the powerful genetic, cellular, and molecular tools now available. Our thesis is that macrophage specialization and functions go far beyond immunobiology, while remaining an essential contributor to innate as well as adaptive immunity.
Reference Key
gordon2019thefrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gordon, Siamon;Plüddemann, Annette;
Journal Frontiers in immunology
Year 2019
DOI
10.3389/fimmu.2019.01893
URL
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