Genome-wide SNP analysis of Japanese Thoroughbred racehorses.

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ID: 39838
2019
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Abstract
The domestication process of plants and animals typically involves intense inbreeding and directional selection for various traits. Here, we genotyped 370 Japanese Thoroughbred horses using the recently developed 670k SNP array and performed various genome-wide analysis also using genotype data of other horse breeds. We identified a number of regions showing interesting patterns of polymorphisms. For instance, the region containing the MC1R locus associated with chestnut coat color may have been targeted by selection for a different mutation much earlier on than the recent selection for chestnut color. We also identified regions that show signatures of selection specific to Thoroughbreds. In addition, we found that intense inbreeding early in the history of the Thoroughbred breed and also before the formation of the breed has a significant impact on the genomic architecture of modern Thoroughbreds. Our study demonstrates that the horse 670k array can be utilized to gain important insight into the domestication process of horses and to understand the genetic basis of the phenotypic diversity in horses.
Reference Key
fawcett2019genomewideplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fawcett, Jeffrey A;Sato, Fumio;Sakamoto, Takahiro;Iwasaki, Watal M;Tozaki, Teruaki;Innan, Hideki;
Journal PloS one
Year 2019
DOI
10.1371/journal.pone.0218407
URL
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